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Main Outcome Measures Self-reported ability to achieve and maintain an erection for sexual intercourse according to the International Index of Erectile Function and adverse events.
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Four experiments were conducted. Experiment one examined the effect of L-NMMA on NMDA mediated behavioral responses in normal rats; experiment two measured behavioral responses to NMDA or sodium nitroprusside (SNP), an NO donor in both control and diabetic rats; the third experiment observed the effect of diabetes on nNOS protein in the PVN; the fourth experiment measured NMDA mediated behavioral responses in diabetic rats after restoring the nNOS protein in the PVN using viral gene transfer.
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Lifestyle choices that contribute to heart disease and vascular problems also raise the risk of erectile dysfunction. Smoking, being overweight, and avoiding exercise are possible causes of ED.
Mechanical Genital trauma or surgery; Peyronie's disease; congenital abnormalities Fibrous penile plaques or chordae None
Advice for women on how to cope with their partner's erectile dysfunction.
The major difference between tadalafil and the other PDE-5 inhibitors is its prolonged half-life of 17.5-21 h compared with sildenafil (4-5 h) and vardenafil (4.8-6 h). In those who respond, coitus has been recorded from 30 min to 36 h after administration.
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