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ED affects 15 to 30 million American men.
Sildenafil (Viagra) was the first oral phosphodiesterase type 5 (PDE5) inhibitor approved by the FDA in the United States for the treatment of erectile dysfunction (it is not approved for women). Sildenafil inhibits PDE5, which is an enzyme that destroys cGMP. By inhibiting the destruction of cGMP by PDE5, sildenafil allows cGMP to accumulate. The cGMP in turn prolongs relaxation of the smooth muscle of the corpora cavernosa. Relaxation of the corpora cavernosa smooth muscle allows blood to flow into the penis resulting in increased engorgement of the penis. In short, sildenafil increases blood flow into the penis and decreases blood flow out of the penis.
Sildenafil (Pfizer) was dissolved in the drinking water (20 mg/kg/24 h), given i.p. daily where indicated (20 mg/kg/24 h), or added to the cell cultures (50 mg/ml). 2 mg/kg/24 h tadalafil (Lilly ICOS) was administered i.p. In vivo treatments started on day 0 unless otherwise indicated.
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Erectile dysfunction is defined as the persistent inability to achieve or maintain penile erection sufficient for sexual intercourse. In the past, patients have underreported this problem because of embarrassment and the belief that little could be done to alleviate it. The availability and marketing of new therapies for erectile dysfunction have greatly increased public awareness of this problem.
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The researchers concluded that under the supervision of a physician, sildenafil can be safely used in conjunction with heart medications. There are insufficient studies on the newer medications vardenafil (Levitra) and tadalafil (Cialis) to draw conclusions, however.
To cash in on this huge and relatively new market, (at least in terms of its acceptance), it is no surprise that numerous pharmaceutical companies are rushing to find new drugs and new methodology, to treat erectile dysfunction.
Article, publication date, and citation information can be found at http://pharmrev.aspetjournals.org.
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What Precautions Should I Take Before Taking One of These Drugs?
Vardenafil (Levitra) was the second oral medicine approved by the United FDA in the US for the treatment of erectile dysfunction. Like sildenafil (Viagra), vardenafil (Levitra) inhibits PDE5 which destroys cGMP (as discussed earlier).
A loss of pubic or armpit hair and an enlargement of the breasts.
Look, I’m not a prude, but I kind of got enough of those freaking Viagra ads during the Major League Baseball playoffs. They’re really fun to watch with your 8 and 10 year old. It’s one of those cases where I appreciated how in the UK, certain types of ads simply could not be shown before a certain hour, when kids were assumed to be bed — or in association with certain kinds of TV shows.
Novel PDE-5 selective inhibitor chemically unrelated to sildenafil and vardenafil. Effective for mild, moderate, and severe ED of varying etiologies, including both organic and psychogenic causes.
28.5 percent of the patients had a history of diabetes, 18.8 percent had heart disease, 37.2 percent had tried Viagra, and 7.5 percent were receiving both Uprima and nitrate therapy for angina.
For whatever reason they were taken, NSAIDs roughly doubled the risk of erectile dysfunction compared with non-use. The presence of arthritis without NSAID use increased the risk of erection difficulty by only 30 percent, the researchers explain, and they therefore conclude that NSAIDs were largely to blame for the link between arthritis and erectile dysfunction.
Erectile Dysfunction: Cialis, Viagra and Levitra to Treat ED
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